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Image Search Results
Journal: Journal of Neuro-Oncology
Article Title: MGMT promoter methylation status for glioblastoma: defining the clinically relevant cut-off value for pyrosequencing
doi: 10.1007/s11060-026-05633-0
Figure Lengend Snippet: Flowchart of patient selection. MGMTpm, MGMT promoter methylation; RT, radiotherapy; TMZ, Temozolomide. * Meningioma, ependymoma, diffuse midline glioma, pilocytic astrocytoma, ganglioglioma, fibrillary astrocytoma, oligodendroglioma IDHmut, gemistocytic astrocytoma IDHmut and germinoma ** Including patients not receiving postoperative treatment. *** preopPS, or extent of resection **** thereby absent from the SQR
Article Snippet: A third option is to establish a cut-off based on outcome, such as in the study by Quillien where the
Techniques: Selection, Methylation
Journal: Journal of Neuro-Oncology
Article Title: MGMT promoter methylation status for glioblastoma: defining the clinically relevant cut-off value for pyrosequencing
doi: 10.1007/s11060-026-05633-0
Figure Lengend Snippet: MGMT promoter methylation status and cut-offs. ( a ) Distribution of mean MGMTpm status of all 451 patients. The solid green line representing the supervised cut-off ( b ) and the dashed black line representing the unsupervised cut-off ( c ). Distributions for each individual CpG are presented in Supplementary Fig. . ( b ) Cut-off supervised by OS and adjusted for prognostic factors: age, extent of resection and preoperative ECOG performance status (solid green line), determined through 5-fold cross-validation with the highest concordance index corresponding to the best performing AFT (accelerated failure time) model. ( c ) Bimodal normal mixture model, with unsupervised cut-off (dashed black line) determined as the intersection point of the two distributions. Blue bars represent patients with methylated MGMT and red bars represent patients with unmethylated MGMT, according to the supervised cut-off (solid green line, b )
Article Snippet: A third option is to establish a cut-off based on outcome, such as in the study by Quillien where the
Techniques: Methylation, Biomarker Discovery